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Administering the Neuropsychiatric Inventory(NPI),we examined the behavioral symptoms of 22 patients with progressive supranuclear palsy (PSP),50 patients with Alzheimer's disease,and 40 controls.PSP patients exhibited apathy(91%),disinhibition(36%),dysphoria(18%)and anxiety(18%), but rarely(<9%)irritability,abnormal motor behaviors,or agitation.Apathy in PSP was significantly associated with executive dysfunction.The presence of high apathy and low agitation and anxiety scale scores correctly identified the PSP patients 85%of the time.Evaluating the behavioral abnormalities of patients with neurodegenerative disorders will aid diagnosis and facilitate management. |
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